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Kaufen Pletal Online

  • €0,74
  • Verfügbarkeit: Lagernd
  • Wirkstoff: Cilostazol
Pletal (Cilostazol) verringert intermittierende Hinkenattacken, die nach einer Spaziergang passieren können.
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100 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,47 €43,99
60 pillen €1,23 €87,99 €74,07
90 pillen €1,16 €131,98 €104,14
120 pillen €1,12 €175,97 €134,22
180 pillen €1,08 €263,96 €194,37
270 pillen €1,05 €395,93 €284,60
360 pillen €1,04 €527,91 €374,82
50 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,16 €34,69
60 pillen €0,93 €69,38 €55,76
90 pillen €0,85 €104,07 €76,82
120 pillen €0,82 €138,76 €97,89
180 pillen €0,78 €208,14 €140,03
270 pillen €0,75 €312,21 €203,22
360 pillen €0,74 €416,28 €266,43

INDICATIONS

Pletal (Cilostazol) widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for other purposes not listed in this medication guide.

INSTRUCTIONS 

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.
Take each dose with a full glass of water. Cilostazol is usually taken twice a day, at least 30 minutes before or 2 hours after breakfast or dinner. Take cilostazol at the same times each day. Follow your doctor's instructions.

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

DOSAGE 

Take cilostazol on an empty stomach, at least 30 minutes before or 2 hours after food.

If you miss a dose of Pletal take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider or pharmacist.

STORAGE 

Store cilostazol at room temperature away from moisture, heat, and light.

MORE INFO:

Active ingredient: cilostazol

Inactive ingredients: carboxymethylcellulose calcium, corn starch, hydroxypropyl methylcellulose 2910, magnesium stearate, and microcrystalline cellulose.

SAFETY INFORMATION

Before taking cilostazol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders (such as bleeding ulcers, bleeding in the eye/brain), congestive heart failure, other heart disease (such as heart attack, chest pain, fast/irregular heartbeat), stroke, kidney disease, liver disease, blood disorders (such as hemophilia, low platelet counts).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.


FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cilostazol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

SIDE EFFECTS

Possible side effects:

Headache, diarrhea, runny nose, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. 

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: fast/pounding/irregular heartbeat, swelling of the hands/feet.

Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, black or bloody stools, vomit that looks like coffee grounds, signs of infection (such as fever, persistent sore throat).

Get medical help right away if any of these rare but serious side effects occur: chest/jaw/left arm pain, fainting, vision changes, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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More Common

  • Fast or irregular heartbeat
  • fever
  • Back pain
  • dizziness
  • gas
  • headache
  • increased cough
  • pain or stiffness in the muscles
  • pounding heartbeat
  • runny or stuffy nose
  • sore throat
  • swelling of the arms or legs

Less Common

  • Abnormal bleeding
  • bloody or black tarry stools
  • bruises or red spots on the skin
  • fainting
  • nausea, heartburn, or indigestion (severe or continuing)
  • nosebleeds
  • stiff neck
  • stomach pain, cramping, or burning (severe)
  • swelling of the tongue
  • vomiting of blood or material that looks like coffee grounds

Incidence Not Known

  • Bleeding gums
  • bleeding tendency
  • blistering, peeling, loosening of the skin
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • coughing up blood
  • dark urine
  • diarrhea
  • difficulty with breathing
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache, sudden and severe
  • inability to speak
  • itching of the eyes
  • itching of the skin
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • nausea and vomiting
  • painful or difficult urination
  • pinpoint red spots on the skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • skin rash
  • slurred speech
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • swollen glands
  • temporary blindness
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arm or leg on one side of the body, sudden and severe
  • weakness of part of the body
  • yellow eyes or skin
  • Bruising
  • feeling of warmth
  • pain
  • redness of the face, neck, arms and occasionally, upper chest
Type Small Molecule
Accession Number DB01166  (APRD00155)
Groups Approved, Investigational
Synonyms
  • 3,4-dihydro-6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone
  • 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone
  • 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril
  • 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-one
  • Cilostazole
  • Cilostazolum
UNII N7Z035406B
CAS number 73963-72-1
Weight Average: 369.4607
Monoisotopic: 369.216475133
Chemical Formula C20H27N5O2
InChI
InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
IUPAC Name
6-[4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy]-1,2,3,4-tetrahydroquinolin-2-one
Protein binding

95-98%

Toxicity

Information on acute overdosage with cilostazol in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias. The oral LD50 of cilostazol is >5.0 g/kg in mice and rats and >2.0 g/kg in dogs.

Half life

11-13 hours.

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