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Kaufen Triamterene Online

  • €0,81
  • Verfügbarkeit: Lagernd
  • Wirkstoff: hydrochlorothiazide
Die Kombination von Hydrochlorothiazid und Triamteren wird zur Behandlung von Flüssigkeitsretention (Ödeme) und Bluthochdruck (Hypertension) angewendet.
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Alle anzeigen

75 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,32 €39,73
60 pillen €1,04 €79,46 €62,56
90 pillen €0,95 €119,19 €85,39
120 pillen €0,90 €158,93 €108,21
180 pillen €0,85 €238,39 €153,87
270 pillen €0,82 €357,58 €222,34
360 pillen €0,81 €476,78 €290,82

Drug Name

Triamterene (Triamterene/ Hydrochlorothiazide) 

Drug Uses

Triamterene pill combines Triamterene and Hydrochlorothiazide. Triamterene ia potassium-conserving (antikaliuretic) diuretic with relatively weak natriuretic properties. Hydrochlorothiazide is a diuretic and antihypertensive agent. It blocks the renal tubular absorption of sodium and chloride ions. 

How to use

Use Triamterene as directed by your doctor. 
Take Triamterene by mouth with food.
If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.
Ask your health care provider any questions you may have about how to use Triamterene.

Drug Class and Mechanism

Triamterene is a potassium-conserving (antikaliuretic) diuretic with relatively weak natriuretic properties. It exerts its diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium in exchange for potassium and hydrogen. With this action, triamterene increases sodium excretion and reduces the excessive loss of potassium and hydrogen associated with hydrochlorothiazide. Triamterene is not a competitive antagonist of the mineralocorticoids and its potassium-conserving effect is observed in patients with Addison's disease, i.e., without aldosterone. Triamterene's onset and duration of activity is similar to hydrochlorothiazide.

Hydrochlorothiazide is a diuretic and antihypertensive agent. It blocks the renal tubular absorption of sodium and chloride ions. This natriuresis and diuresis is accompanied by a secondary loss of potassium and bicarbonate. Onset of hydrochlorothiazide's diuretic effect occurs within two hours and the peak action takes place in four hours. Diuretic activity persists for approximately six to twelve hours.

Missed Dose

If you miss a dose of Triamterene and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. 

Storage

Store Triamterene at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Triamterene out of the reach of children and away from pets.

Warnings/Precautions

Do not use Triamterene if: 
you are allergic to any ingredient in Triamterene;
you are taking potassium supplements, another potassium-sparing diuretic (e.g., amiloride), or an aldosterone blocker (e.g., eplerenone);
you are unable to urinate or have high blood potassium levels or severely decreased liver or kidney function.
Contact your doctor or health care provider right away if any of these apply to you.

Important:

Triamterene may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Triamterene with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Check with your doctor before you use a salt substitute or a product that has potassium in it.
Tell your doctor or dentist that you take Triamterene before you receive any medical or dental care, emergency care, or surgery.
Lab tests, including blood electrolytes, blood cell counts, kidney and liver function tests, blood uric acid levels, and blood pressure, may be performed while you use Triamterene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Triamterene with caution in the elderly; they may be more sensitive to its effects.
Triamterene should not be used in children; safety and effectiveness in children have not been confirmed.
Pregnancy and breast-feeding: It is not known if Triamterene can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Triamterene while you are pregnant. It is not known if Triamterene is found in breast milk. Do not breast-feed while taking this medicine.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome: 
diarrhea; headache; loss of appetite; nausea; weakness.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; slow or irregular heart rate; unusual muscle weakness; unusual tiredness; vomiting; yellowing of the skin or eyes.

More Information

Triamterene is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

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Incidence Not Known

  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chills
  • clay-colored stools
  • cloudy urine
  • confusion
  • convulsions
  • cough
  • dark urine
  • decreased urine output
  • depression
  • difficulty breathing
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting spells
  • fast or irregular heartbeats
  • fever
  • headache
  • hives
  • hostility
  • increased thirst
  • irritability
  • itching
  • joint pain
  • lethargy
  • loss of appetite
  • loss of consciousness
  • mood changes
  • muscle pain or cramps
  • muscle twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain in the groin or genitals
  • pain in the lower back or side
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rapid or unusual weight gain
  • seizures
  • sharp back pain just below the ribs
  • shortness of breath
  • skin rash
  • stupor
  • swelling of the face, ankles, feet, or hands
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weakness or heaviness of the legs
  • wheezing
  • yellow eyes or skin
  • Increased sensitivity of skin to sunlight
  • redness or other discoloration of the skin
  • severe sunburn
Type Small Molecule
Accession Number DB00384  (APRD00079)
Groups Approved
Synonyms
  • 6-phenylpteridine-2,4,7-triamine
  • Teridin
  • Triamteren
  • Triamtérène
  • Triamterene
  • Triamtereno
  • Triamterenum
UNII WS821Z52LQ
CAS number 396-01-0
Weight Average: 253.2626
Monoisotopic: 253.107593387
Chemical Formula C12H11N7
InChI
InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
IUPAC Name
6-phenylpteridine-2,4,7-triamine
Protein binding

55-67% (93% for the OH-TA-ester metabolite)

Toxicity

In the event of overdosage it can be theorized that electrolyte imbalance would be the major concern, with particular attention to possible hyperkalemia. Other symptoms that might be seen would be nausea and vomiting, other G.I. disturbances, and weakness. It is conceivable that some hypotension could occur. The oral LD50 in mice is 380 mg/kg.

Half life

255 minutes (188 minutes for OH-TA-ester metabolite) after IV administration.

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